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Keywords: Acetic acid , anti-inflammatory agents , colitis , rats , ulcerative , vitamin B complex Introduction Ulcerative colitis (UC) is a chronic inflammatory bowel disease (IBD) with an unknown etiology that affects the colon and rectum.[1] There are many responsible factors for increasing susceptibility to UC, such as genetics, disorder of the immune system, environmental factors, and nutritional habits, including foods with saturated fats and low fibers.[2] Malnutrition and lack of micronutrients are common problems in more than half of these patients.[3] Reduction in food intake, anorexia, food abstinence, malabsorption, and nutrient-drug interactions are some of the various reasons that can lower vitamins and mineral absorption