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Inflammatory factors such as tumor necrosis factor- (TNF-), interleukin-1 (IL-1) and lipopolysaccharide (LPS), as well as hypoxia-inducible factor (HIF), vascular endothelial growth factor (VEGF), high glucose, high salt and lead, can upregulate ESM1 (2426)

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Furthermore, under normal physiological conditions following birth, term newborns readily acquire sufficient L-carnitine through enteral feeds

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