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3.2 GSH consumption and hydroxyl radical (OH) production GSH overexpressed in tumor cells can reduce Cu 2+ in Cu/ZIF8 to Cu + , which acts as a potent Fenton-like reagent capable of generating abundant OH when combined with H 2 O 2

Synergistic combinations with vitamin C, retinoids, and other peptides Combining GHK-CU with synergistic ingredients like vitamin C, retinoids, or other peptides can amplify its effects and address multiple skin concerns simultaneously

long-term safety data is limited

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Copper peptides are photosensitive enough that an amber vial or aluminum-foil wrap is a reasonable precaution for any vial that will be drawn from over multiple weeks