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Safety, tolerability, and exploratory indicators of mitochondrial functioning were included among the secondary objectives ( Another 2021 open-label, single-center Phase I trial NCT04976127 looked at the safety, tolerability, and pharmacokinetics of intravenous TalineurenTM (TLN), a liposomal GM1 ganglioside for PD

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DGL is typically dosed in the range of 150-300 mg daily, and even higher dosages used for short term healing are safe (up to 1800mg per day has been studied as safe to use for 4 weeks)

2,3 Sorafenib is a multikinase inhibitor that is used to treat patients with unresectable HCC

Synergy effect and multitarget effect Tumor progression involves complex molecular networks, making single-target therapies prone to failure due to interpatient heterogeneity and adaptive mechanisms such as target downregulation and MDR