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Description

In IBD, the expression levels of tight junction proteins such as ZO-1 and Occludin, is generally suppressed, leading to increased intestinal permeability, enhanced pathogen infiltration, and exacerbated inflammatory responses (Dong et al., 2022)

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Furthermore, the mechanical characteristics of the ECM play a significant role in modulating T cell activation and proliferation in ovarian and pancreatic cancers (85)

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1988, 4.Downey D., Larrabee W

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