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Hill DB, Button B, Rubinstein M, Boucher RC

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Nasal administration may actually require higher quality standards since contamination would contact sensitive nasal mucosa rather than subcutaneous tissue that handles minor contamination more readily

Endothelial ion transporters, including the Na-H and Na-K-Cl cotransporter, become dysregulated upon neuronal injury, resulting in an imbalance of ionic gradients and cytotoxic edema that contribute to secondary neuronal damage (Pinheiro et al., 2016)

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