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Potential limitations include: Limited long-term human data Variable patient response Cost considerations Need for ongoing monitoring Off-label prescribing considerations These therapies are generally avoided in patients with: Active malignancy Pregnancy or breastfeeding Significant uncontrolled endocrine disease Certain metabolic conditions Monitoring and Safety Where prescribed, monitoring may include: IGF-1 levels Functional recovery Sleep quality Rehabilitation tolerance Adverse effects Overall clinical progress Treatment should always be part of a broader recovery plan rather than a standalone intervention

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The impact of HIV- and ART-Induced mitochondrial dysfunction in cellular senescence and aging