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For example, Sarne et al

In turn, Oprm1 -KO mice treated with oxytocin exhibited altered expression levels of genes encoding oxytocin, vasopressin, and dopamine receptors within the CPu, NAc, VP/Tu, MeA, and CeA regions (for details, see Table 2) [42]

Chronic constipation patients, particularly those with STC, also demonstrate increased pro-inflammatory cytokine levels (Barbara et al., 2004)

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In addition, ratios of the concentration of metabolites can provide a normalization effect that reduces variation due to unrelated biological or analytical sources leading to higher specificity in diagnostic analyses (34)