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Under normal conditions, LESs tonic pressure surpasses that of the stomach, effectively preventing the reflux of gastric contents (Reference Mittal, Fisher and McCallum22)

The Patient-Reported Outcome Measurement Information System (PROMIS-10), which measures a combination of physical, mental, and social determinants of health [55], as well as the NeuroQoL-fatigue, an 89 question survey about fatigue [56], correlate with ALSFRS-R scores [57] and are being incorporated more consistently across neurology trials, but are not specific to ALS

Nature 603:503508 Silva GM, Finley D, Vogel C (2015) K63 polyubiquitination is a new modulator of the oxidative stress response

Antioxidant Protection: Glutathione is a powerful antioxidant that protects skin cells from damage caused by free radicals and environmental stressors