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In contrast, the metabolite trimethylamine N-oxide (TMAO), GM-derived, is associated with the increased phosphorylation of tau proteins and cognitive impairment, underlining the importance of a healthy GM in preventing neuroinflammation and neurodegeneration [32,37]

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Acknowledgments The Figures 1 5 were created with Biorender.com

Ivankovic S, Stojkovic R, Jukic M, Milos M (2006) The antitumor activity of thymoquinone and thymohydroquinone in vitro and in vivo

Identification and quantification of innate immune system mediators in human breast milk