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They mitigate inflammation, crucial for managing skin conditions like eczema and psoriasis ( 2.5 NRF2 In the mechanism of ferroptosis, NRF2 plays a central regulatory role ( Under conditions of oxidative stress, NRF2 can dissociate from the cytosolic protein Kelch-like ECH-associated protein 1 (KEAP) to which it is bound, and rapidly translocate to the nucleus ( Moreover, NRF2 finely regulates key genes in the iron metabolism pathway, such as ferroportin, a protein that promotes the export of iron ions out of the cell ( NRF2 plays a pivotal role in maintaining skin health