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High dose melatonin increases sleep duration during nighttime and daytime sleep episodes in older adults

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Additionally, both pathways enhance mitochondrial function and reduce levels of reactive oxygen species (ROS) levels (187191) and reduce oxidative stress (187, 192)

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Wogonoside seems to alleviate colitis by protecting against intestinal barrier dysfunction through the reinforcement of tight junctions via regulation of the MLCK/pMLC2 signaling pathway in Caco2 cells [105], whereas in DSS-induced UC mice this compound seemed to lead to dual inhibition of NF-B and NLRP3 inflammasome [106]