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Stimulating Regeneration and Connectivity (bottom right, orange): Techniques like PTEN inhibition and neuromodulation (e.g., deep brain stimulation or chemogenetics) promote axonal growth and reconstitution of neural circuits

doi: 10.1038/nm.4407

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Findings in this timeframe include increases in lean tissue mass and reductions in fat mass, particularly in visceral and abdominal depots, consistent with IGF-1 LR3s documented dual role in anabolic and lipolytic signaling