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While alternative administration routes, such as intravenous, intramuscular, nasal, percutaneous, and transdermal delivery, have shown promise in certain conditions, these methods can be invasive and uncomfortable for patients

The peptide works by triggering sustained gene expression changes that require consistent signaling

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As crucial regulators of local immune responses and tissue repair, macrophages in diabetic wounds show dysregulated switching from M1 to M2, resulting in a poor regenerative environment, exacerbated tissue damage, and delayed wound healing 63