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These results indicate that OTA induces phase I and II enzymes through the AhR, PXR, and Nrf2 signaling pathways in HK-2 cells, which may lead to the modulation of proximal tubule injury (Lee et al., 2018)

The resulting ligand-proteins complexes were aligned to match the position of the co-crystallized small molecule fragments

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However, in certain cases, this response can inadvertently damage host cells or tissues that are not typically targeted