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Disruptions in energy homeostasis and metabolism emerge in ALS and are considered central to disease pathogenesis 11,12

WangLLiuYDuTYangHLeiLGuoMet al

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Molecules that recognize these highly expressed proteins can be used for neovascular-based targeted drug delivery

Oxidative stress reactions, particularly the excessive generation of reactive oxygen species (ROS), may interfere with the function of the hypothalamic-pituitary-adrenal (HPA) axis, leading to hormonal imbalances that impact sleep and physical stamina (Spiers et al., 2015)