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(2020) reported that irisin activates the Nrf2 pathway, which is known to regulate proteasomal function and oxidative stress responses, potentially contributing to reduced protein aggregation 33

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Proper control of ROS levels is also crucial for cytokinesis

Excess copper is reduced by FDX1 to generate Cu, which drives cell death via two primary mechanisms: (1) Cu-mediated aggregation of lipoylated TCA cycle proteins (e.g., DLAT) and loss of Fe-S clusters, and (2) Cu-induced disruption of the Npl4/p97 protein quality-control system