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Additionally, the levels of protein expression of Nrf2 and NQO1 were reversed by two activators of Nrf2, bardoxolone (CDDO) and sulforaphane (SFN)

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Non-human primates (NHPs), such as rhesus monkeys, naturally exhibit age related tau and amyloid (A) pathologies, providing models that closely mimic human disease progression (Li et al., 2019)