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Sandson: The two issues to pay attention to are toxicity and loss of efficacy

PLOS ONE 6 , e22652 (2011)

used intrinsic fluorescence to characterize interaction of MBP with divalent cations and showed that Zn 2+ can bind to MBP (Cavatorta et al., 1991)

Introduction Cognitive decline may occur for a variety of reasons, including the accumulation of senescent cells, 1 excessive oxidative stress, 2 mitochondrial dysfunction, 3 loss of apoptosis, 4 environmental toxins 5,6 depletion of stem cells, 7 telomere shortening, 8 inefficient cell communication, 9 epigenetic alterations 10 and neuroinflammation