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Typhi allows bacteria to upregulate the expression of 35 genes related to the membrane matrix and antibiotic resistance ( STY1254, STY1255, yheA , etc.), downregulated 29 genes related to metabolic processes and biofilm regulation ( STY1856, yiiU, cspB , etc.), and enter a state of energy conservation in response to the stressful environment (Chin et al., 2017)

TMAO reduces synaptic plasticity and induces cognitive dysfunction by promoting endoplasmic reticulum stress and directly binding to activate PERK, which damages synaptic plasticity (Zhang et al., 2007

Gut microbiota-dependent trimethylamine n-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease

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2. May Enhance Energy During Workouts