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Duration: benefits may last 12-18 months or more, but repeat treatments may be needed

A number of surgical strategies have been described, but there is insufficient evidence to advocate one repair technique over another

whereas stiffer substrates promote osteogenic differentiation (Navaro et al., 2015

Your body produces thousands of them

Standard Dosing Range: Low dose: 200 to 250 mcg once daily Moderate dose: 250 to 500 mcg once or twice daily Higher dose: 500 to 800 mcg once or twice daily Weight-Based Dosing: Based on animal study extrapolations, an estimated human equivalent dose is approximately 1.6 mcg/kg body weight, translating to roughly 110 mcg for a 150-pound person and 145 mcg for a 200-pound person when using oral administration