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The observed accumulation of GSH in Sp treated cells was probably due to reduced activity of -glutamyl transpeptidase (GGT), an enzyme responsible for glutathione catabolism 36

Adv Neurobiol 11:1330 Dringen R, Pawlowski PG, Hirrlinger J (2005) Peroxide detoxification by brain cells

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However, one study reported that fentanyl causes an increase in production of reactive oxygen species in freshly isolated peripheral blood lymphocytes 118 , which arguably may involve a reduction in cellular reduced thiol levels