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Iron chelators could therefore be a potential therapeutic option for patients with high iron levels

Adaptive immune cells can also stabilize HIF-1 through oxygen-independent mechanisms (Figure 1B)

The standard treatment includes surgery and platinum-based chemotherapy, but there has been increasing use of anti-angiogenic Bevacizumab and Poly(ADP-ribose) polymerase (PARP) inhibitors in the past decade [296]