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These differences were recently revealed to have a fundamental impact on the outcome of antagonist engagement of FcRn, as a direct comparison of recombinant versions of efgartigimod (ARGX-113) and two other pipeline antagonistsbatoclimab (HL161BK) and nipocalimab (N027)revealed differential effects on the subcellular trafficking of FcRn [237]

10.1038/nri749 Nat

Shuai, S, Abascal, F, Amin, S, Bader, GD, Bandopadhayay, P, Barenboim, J, Beroukhim, R, Bertl, J, Boroevich, KA, Brunak, S, Campbell, PJ, Carlevaro-Fita, J, Chakravarty, D, Chan, CY, Chen, K, Choi, JK, Deu-Pons, J, Dhingra, P, Park, K, Akbani, R, Aldape, KD, Broaddus, R, Borresen-Dale, A, Cao, S, Chen, Y, Czerniak, BA, Eils, R, El-Naggar, AK, Fan, Y, Gershenwald, JE, Han, L, Huse, J, von Kalle, C, Krishnamurthy, S, Langerod, A, Lazar, A, Li, J, Liang, H, Lichter, P, Lu, Y, Mills, GB, Sood, AK, Su, X, Thompson, A, Van Loo, P, Wang, L , Wang, W, Weinstein, JN, Yuan, Y, Zhu, H

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