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doi: 10.3389/fphys.2024.1243629 Received 21 June 2023 Accepted 22 January 2024 Published 31 May 2024 Volume 15 - 2024 Edited by Mark Edward Wylam, Mayo Clinic, United States Reviewed by Sudhahar Varadarajan, Augusta University, United States Zhuoyue Bi, Stony Brook University, United States Updates Copyright 2024 Song, Yue, Zhang and Wang

Patient samples The hypothyroidism sample (N = 40) included the following co-occurring diagnoses and conditions (N = 21) made at least 1 year before starting L-carnitine supplementation in the study: hypertension (N = 6), type 2 diabetes (N = 6), sleep apnea managed with CPAP treatment (N = 3), Sjgrens Syndrome (N = 2), vitiligo (N = 2), hypercholesteremia (N = 2), menopausal symptoms (N = 2), asthma (N = 1), celiac sprue (N =1), and Menieres Disease (N = 1)