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This work represented a methodological step forward in 1 H-MRS studies in ASPD, in that use of 3T MRI scanner with MEGA-PRESS allowed for a direct measure of GABA (GABA+), and hence a metric of E/I balance in the form of glutamate : GABA ratio, which has not been reported in this group before

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Whilst some studies found beneficial effects in patients with AD 36 and dementia 90 and in shift workers, 91 others found no improvements in patients with sleepwake rhythm disorders