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constructed a metalphenolic network (TBFP-MT MPN) system based on PEG-polyphenol, which reduces drug efflux by inhibiting mesenchymalepithelial transition signaling and blocking pyrimidine synthesis through the inhibition of dihydroorotate dehydrogenase (DHODH), thereby lowering the levels of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) and enhancing TMZ cytotoxicity (150)

[8] A review and meta-analysis in 2009 found the benefits of its use inconclusive

[DOI] [PMC free article] [PubMed] [Google Scholar] 92.VRINGER E, TAIT S W G

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