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its actions were thought to be primarily excitatory in the developing brain

Production declines with age, however, sometimes to the point where levels are too low to properly protect the body

It can be objectively identified and quantified using validated clinical, imaging, and biomarker-based tools, is strongly associated with exacerbations, lung function decline, and mortality, and is amenable to targeted intervention

Medically reviewed by Oghenefejiro Okifo | MD , Harvard Medical School | Henry Ford Hospital - Detroit, MI on June 13th, 2025

In the 6-OHDA-induced PD model, iron promotes LRRK2 activation via phosphorylation at S935 and S1292 sites