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NCOA4-mediated ferritinophagy has been shown to trigger ferroptosis by degrading ferritin and inducing iron overload [31]

Also, severe symptoms at baseline along with the predominance of certain kinds of bacteria predicted a favorable response to the low-FODMAP diet: American Journal of Clinical Nutrition 2021: Low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols diet compared with traditional dietary advice for diarrhea-predominant irritable bowel syndrome: a parallel-group, randomized controlled trial with analysis of clinical and microbiological factors associated with patient outcomes [moderate evidence] This study showed that a low-FODMAP diet was superior to traditional dietary advice, though compliance with the diet dropped from 93% at 4 weeks to 64% at 16 weeks: Journal of Gastroenterology and Hepatology 2021: Low fermentable oligosaccharide, disaccharide, monosaccharide, and polyol diet in patients with diarrhea-predominant irritable bowel syndrome: A prospective, randomized trial [moderate evidence] Digestive Diseases and Sciences 2006: A very low carbohydrate diet improves gastroesophageal reflux and its symptoms

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