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A B12 shot is an intramuscular injection that delivers vitamin B12 directly into muscle tissue, while a B12 IV infusion delivers B12 alongside hydrating fluids and complementary nutrients directly into the bloodstream through a vein

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If the administration of a B vitamin supplement causes skin problems, such as the resurgence of juvenile acne, this may be due to a high vitamin B12 level in the skin or higher doses of vitamin B6 (pyridoxine)

If pernicious anaemia is suspected, testing for intrinsic factor antibodies and gastric parietal cell antibodies may be appropriate