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Therefore, pre-operative mapping of MIS margins serve as the necessary tool for conservative curative surgery in larger melanoma in situ lesions or in those with poorly defined borders

7-9 MRI is useful in distinguishing them from other tumors, as MMNSTs have intrinsic T1 hyperintensity (Figure 1), while schwannomas and neurofibromas tend to be hypointense on T1 and hyperintense on T2

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Taken together with the findings of routine histopathologic examination and IHC, this genomic profile, with mutation in PRKAR1A only and monosomies of multiple chromosomes, including 1, 2, and 17, was diagnostic for MMNSTs