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Across rodent studies, ATX-304 has been reported to: Activate AMPK in liver, adipose tissue and kidney tubules Shift cells away from lipid accumulation and toward oxidative metabolism Reduce fat mass and improve blood lipids in obese or insulin-resistant mouse models Protect kidney tissue against energetic stress in models of diabetes and acute kidney injury In diet-induced obesity models, feeding mice ATX-304-containing chow led to weight loss and body-fat reduction , even when food intake was maintained or slightly increased