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To facilitate the calculations and analysis, an artificial chimera molecule was built using the X-ray fragments found in subpockets A-C in PDB:6FP4 and PDB:6FTC and connected by a short CH 2 CH 2 linker

Spermidine delays aging through multiple pathways, such as the activation of autophagy, the regulation of epigenetic modifications, the improvement of mitochondrial function and the inhibition of inflammation, and has shown potential for improving healthspan in model organisms (yeasts, Drosophila , nematodes, and mice) 429 and humans

This might be explained by the fact that although EAAT2 and KYNA might be downregulated, there is also a downregulation of system x activity

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