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As we age, NAMPT doesn't work as well, which leads to lower NAD+

Frequently Asked Questions Can I take vitamin B12 shots without a prescription

Because of this difference, taking them together or separately does not reduce their effectiveness

In fact, one study found that peoples bodies absorbed about 49% of a 1-mcg dose of cyanocobalamin, compared to 44% of the same dose of methylcobalamin ( Conversely, another study comparing the two forms reported that about three times as much cyanocobalamin was excreted through urine, indicating that methylcobalamin may be retained better within your body ( However, some research suggests that differences in bioavailability between the two forms may be insignificant and that absorption could be influenced by factors such as age and genetics ( Unfortunately, recent research directly comparing these two forms of vitamin B12 is limited

How do gastrointestinal disorders affect vitamin B12 absorption