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doi: 10.1038/s41419-021-04429-6 124 ParkesEEKennedyRD

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Figure 1: Kaplan-Meier Curve for Overall Survival in KEYNOTE-189* *Based on the protocol-specified final OS analysis Initial Treatment in Combination with Cisplatin The efficacy of pemetrexed was evaluated in Study JMDB (NCT00087711), a multi-center, randomized (1:1), open-label study conducted in 1725 chemotherapy-naive patients with Stage IIIb/IV NSCLC

Expected timeline: Week 1 to 3: Reduction in inflammation, improved mobility, some pain relief Week 3 to 6: Significant improvement in nerve symptoms, increased functional capacity Week 6 to 12: Continued tissue remodeling, disc structural improvements Month 3 to 6: Full benefits of the protocol become apparent as remodeled tissue matures Understanding proper peptide storage is critical during multi-week protocols