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Critically ill COVID-19 patients have reduced levels of Tregs and interferon-gamma, so this balance is lost when SARS-CoV-2 infection occurs [51]

Yang, W.S., SriRamaratnam, R., Welsch, M.E., et al

While FA-97 increased overall antioxidant capacity in DSS-treated mice and LPS-treated BMDMs and RAW 264.7 cells, it also decreased ROS and MDA production

This peroxidation occurs via two major pathways: the enzymatic pathway, mediated by lipoxygenases (LOXs), cytochrome P450 oxidoreductase (POR), and NADPH oxidases (NOXs), promotes the generation of PUFA-PL-OOHs, leading to the accumulation of reactive aldehydes, ketones, and other toxic metabolites, ultimately disrupting membrane integrity and triggering ferroptosis (Maheshwari, 2023)

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