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This burst of GH: Triggers fat breakdown (lipolysis) Stimulates IGF-1 production by the liver Enhances protein synthesis and tissue repair Promotes better sleep and cognitive clarity Because its pulsed not constant the body avoids receptor downregulation and maintains feedback sensitivity

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For GH-focused studies where caloric intake or feeding behavior is a confounding variable, that distinction makes ipamorelin significantly more tractable than full ghrelin agonists

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