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Funding This work was funded by the Coimbra Chemistry Centre, which is supported by the Fundao para a Cincia e a Tecnologia (FCT) through the programmes UID/QUI/00313/2020 and COMPETE, and PhD grant (SFR/BD/146358/2019), and also by the project BIOSHELL, Ref

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Mutagenesis and structural modeling implicate RME-8 IWN domains as conformational control points