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10.3390/ijms24021291 138 MolnarM.KovacM

In our hands, the incubation of thiol antioxidants increased the expression of MMP-1 and 3 (Figure 4)

Elevated levels of pro-inflammatory cytokines, such as Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-), directly interfere with insulin receptor signaling in peripheral tissues

Pubmed Central PMCID: PMC5374731

Although GSH conjugation predominates at therapeutic APAP doses, GST-mediated detoxification becomes increasingly important as hepatic GSH levels decline during overdose (Coles et al