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Lorenzen et al., 2017

There appears to be cross-talk between motor neurons, astrocytes, and immune cells, including microglia and T-lymphocytes, which are subsequently activated

Low plasma content of tryptophan has been reported in patients with depression ( Compared with CUMS group, the content of brain metabolites in the ZZCD group was reversed to the normal level, and the disturbed metabolic pathways were restored, which suggesting the antidepressant effect of ZZCD on CUMS rats and revealing the underlying mechanism associated with the improvement of brain metabolism in Phenylalanine, tyrosine and tryptophan biosynthesis, Glutathione metabolism, Phenylalanine metabolism, Lysine degradation, Cysteine and methionine metabolism, Tyrosine metabolism, and Tryptophan metabolism

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Beyond these thresholds, degradation accelerates significantly