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Description

In order to investigate the scientific progress achieved so far in understanding the role of oxidative stress in this dermatological illness, we investigated the associations between different parameters of the antioxidant status, the total oxidative capacity and the severity of psoriasis, the role in psoriasis of different genetic polymorphisms in enzymes involved in the redox balance, as well as the influence of certain topical or systemic treatments routinely applied in psoriasis on the redox balance

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HNE inhibits pyroptosis independent of Nrf2 signaling Nrf2, an antioxidant transcription factor, has been proposed to regulate NLRP3 inflammasome activation (30-32)

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Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

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