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doi: 10.1016/j.humimm.2016.07.008 87 LiW.LiuY.ZhengX.HanJ.ShiA.WongC

Expected outcomes based on trial data: Average weight loss of 24.2% at 48 weeks (phase 2) Average weight loss of 28.7% at 68 weeks (phase 3, TRIUMPH-4) 100% of participants achieved 5% or greater weight loss 93% achieved 10% or greater 83% achieved 15% or greater Moderate weight loss protocol (8mg target) For researchers who want significant weight loss but have a lower tolerance for side effects, stopping the escalation at 8mg is a validated approach

Incapsula incident ID: 1350000740237085643-521094861555110540

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melanogaster gene, ND-18, an ortholog of the human NDUFS4 recapitulates the feeding difficulty observed in humans with a defect in this complex I gene (Foriel et al., 2018)