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More Regular Menstrual Cycles and Improved Fertility Cycle irregularity is common in PCOS, especially when insulin resistance or high androgens are involved

Metformin significantly improves IR and hyperandrogenism, and its combination with CC enhances its ovulation-inducing effect (21, 22)

Mol Aspects Med 25:551567

however, the technology exists in early form such as experiments in using the prepro-orexin transgene via gene editing restored normal function in mice models by making other neurons produce orexin after the original set have been destroyed, or replacing the missing orexinergic neurons with hypocretin stem cell transplantation, are both steps in that direction for fixing the biology effectively permanently once applied in humans