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Preventing Receptor Desensitization Receptor desensitization is a complex cellular process where a cell's response to a stimulus decreases after repeated or prolonged exposure to that stimulus

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1A) to immunoprecipitate HA-SUMO bound proteins under denaturing conditions to disrupt non-covalent protein interactions, we found that TDP-43 becomes SUMOylated by SUMO2 and can form polySUMO chains specifically in response to stress (Fig