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Pan et al., 2025

By conceptualizing uric acid biology as a dynamic, multi-state process, this review offers an integrated perspective on hyperuricemia-associated diseases and suggests directions for future targeted therapeutic research

discovered that the accumulation of unfolded proteins in the mitochondrial matrix resulted in transcriptional upregulation of nuclear-encoded mitochondrial stress genes, including hsp60, hsp10, mtDnaJ, and ClpP, without interfering gene expression that was related to endoplasmic reticulum (ER) stress

Additionally, no decrease in disc height and no change in Pfirrmann score were reported, with 3 patients showing signs of increased NP hydration at the final follow-up

14 Regulation of FAs other than MUFAs may also prove valuable, given the report that arachidonic acid (20:4) promotes the formation of helical S multimers, and these may resist fibril formation and result in reduced neuronal damage