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This is different from proteins that merely have a selenium as a co-factor, such as the glutathione peroxidases (the GPX family, of which GPX4 is a member), and Sec is unlike post-translationally modified amino acids such as arginine-to-citrulline or the various phosphorylations of serine, threonine, and tyrosine, among others, since Sec is incorporated directly into a growing polypeptide chain by a ribosome

Based on this information, they were able to make specific mutations that enhanced stability compared to the native protein

Avoid layering with Benzoyl Peroxide because it deactivates Vitamin C and reduces effectiveness