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Carnitine deficiencies may be caused by genetic disorders, liver or kidney problems, high-fat diets, certain medications, and low dietary levels of the amino acids lysine and methionine (substances needed to make carnitine)

Overall, our reported findings combined with PDH representing a likely effective anti-biofilm therapy, have the potential to impact areas of medical biofilm research beyond chronic wounds

The implications of this low certainty of evidence suggest that our confidence in the effect estimates is limited, and that the true effects may differ substantially from the reported findings

doi: 10.1002/mrd.23542

The addition of the acetyl group makes the molecule more lipophilic (fat-soluble), allowing it to interact uniquely with specialized transport proteins in the body, fundamentally changing where it can go and what it can do once it gets there