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The lateral root polysaccharides of Aconitum carmichaelii (RFP) had the cytotoxicity effects on hydrogen peroxide-induced injury and prohibited apoptosis in vitro, by contrast, RFP attenuated cisplatin-induced acute kidney injury in vivo through inhibition of ferroptosis with the increased levels of GSH and GPX4, the decreased levels of MDA and 4-hydroxynonenal as well as the reduced lipid peroxidation (Tian et al., 2022)

In the mevalonate pathway, the enzyme 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase, which converts HMG-CoA into mevalonate, is common to the biosynthetic pathways of both coenzyme Q 10 and cholesterol and is inhibited by statins (cholesterol-lowering drugs

Pragmatic constraints precluded measurement of water and metabolite T1 and T2 relaxation times in individual subjects

doi: 10.9778/cmajo.20170070 [DOI] [PMC free article] [PubMed] [Google Scholar] Karan L, Makenov M, Kolyasnikova N, Stukolova O, Toporkova M, and Olenkova O (2018)

Partial correlation analysis between metabolites revealed that MET, TYR, and TRP formed a tight cluster of interacting molecules in these MDD patients