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Pioglitazone, a diabetes medication, may benefit selected patients with biopsy-proven NASH, but is also specialist-led and off-label , with potential risks including weight gain, fluid retention, heart failure, and increased fracture risk

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In 1935, Harington and Mead reported a chemical method of glutathione synthesis which paved the foundation for the potential commercial production of glutathione [28]

Unlike the traditional one drug, one target model, this approach conceptualizes disease as a perturbation of biological networks and seeks agents capable of restoring system-wide homeostasis through multi-component interventions