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Description

a review of laboratory, animal, and human studies

Eur J Neurol 2002

It plays a crucial role in upholding the functioning of the nervous system

Severe symptoms may require hospitalization

Similar to the in vitro hMOR binding and functional studies, mitragynine also exhibited the weakest antinociceptive effect (E max 17.3%) among the tested alkaloids at the highest dose tested (10 mg/kg, i.v.)